IronSulferCluV1, Main, Exploration, bibRecord, 000006

Two Distinct L-Lactate Dehydrogenases Play a Role in the Survival of Neisseria gonorrhoeae in Cervical Epithelial Cells.

Identifieur interne : 000006 ( Main/Exploration ); précédent : 000005; suivant : 000007

Two Distinct L-Lactate Dehydrogenases Play a Role in the Survival of Neisseria gonorrhoeae in Cervical Epithelial Cells.

Auteurs : Nathan H. Chen [Australie] ; Cheryl-Lynn Y. Ong [Australie] ; Jonathan O'Sullivan [Australie] ; Ines Ibranovic [Australie] ; Krystelle Davey [Australie] ; Jennifer L. Edwards [États-Unis] ; Alastair G. Mcewan [Australie]

Source :

The Journal of infectious diseases [ 1537-6613 ] ; 2020.

RBID : pubmed:31541571

Descripteurs français

KwdFr :
- ARN viral (génétique), Cellules épithéliales (microbiologie), Col de l'utérus (cytologie), Délétion de gène (MeSH), Femelle (MeSH), Fer (métabolisme), Gonorrhée (microbiologie), Gonorrhée (métabolisme), Humains (MeSH), L-Lactate dehydrogenase (génétique), L-Lactate dehydrogenase (métabolisme), Neisseria gonorrhoeae (croissance et développement), Neisseria gonorrhoeae (enzymologie), Neisseria gonorrhoeae (génétique), Protéines bactériennes (génétique), Protéines bactériennes (métabolisme), Régulation de l'expression des gènes bactériens (MeSH), Viabilité microbienne (génétique).
MESH :
- croissance et développement : Neisseria gonorrhoeae.
- cytologie : Col de l'utérus.
- enzymologie : Neisseria gonorrhoeae.
- génétique : ARN viral, L-Lactate dehydrogenase, Neisseria gonorrhoeae, Protéines bactériennes, Viabilité microbienne.
- microbiologie : Cellules épithéliales, Gonorrhée.
- métabolisme : Fer, Gonorrhée, L-Lactate dehydrogenase, Protéines bactériennes.
- Délétion de gène, Femelle, Humains, Régulation de l'expression des gènes bactériens.

English descriptors

KwdEn :
- Bacterial Proteins (genetics), Bacterial Proteins (metabolism), Cervix Uteri (cytology), Epithelial Cells (microbiology), Female (MeSH), Gene Deletion (MeSH), Gene Expression Regulation, Bacterial (MeSH), Gonorrhea (metabolism), Gonorrhea (microbiology), Humans (MeSH), Iron (metabolism), L-Lactate Dehydrogenase (genetics), L-Lactate Dehydrogenase (metabolism), Microbial Viability (genetics), Neisseria gonorrhoeae (enzymology), Neisseria gonorrhoeae (genetics), Neisseria gonorrhoeae (growth & development), RNA, Viral (genetics).
MESH :
- chemical , genetics : Bacterial Proteins, L-Lactate Dehydrogenase, RNA, Viral.
- chemical , metabolism : Bacterial Proteins, Iron, L-Lactate Dehydrogenase.
- cytology : Cervix Uteri.
- enzymology : Neisseria gonorrhoeae.
- genetics : Microbial Viability, Neisseria gonorrhoeae.
- growth & development : Neisseria gonorrhoeae.
- metabolism : Gonorrhea.
- microbiology : Epithelial Cells, Gonorrhea.
- Female, Gene Deletion, Gene Expression Regulation, Bacterial, Humans.

Abstract

L-lactate is an abundant metabolite in a number of niches in host organisms and represents an important carbon source for bacterial pathogens such as Neisseria gonorrhoeae. In this study, we describe an alternative, iron-sulfur cluster-containing L-lactate dehydrogenase (LutACB), that is distinct from the flavoprotein L-lactate dehydrogenase (LldD). Expression of lutACB was found to be positively regulated by iron, whereas lldD was more highly expressed under conditions of iron-limitation. The functional role of LutACB and LldD was reflected in in vitro studies of growth and in the survival of N gonorrhoeae in primary cervical epithelial cells.

DOI: 10.1093/infdis/jiz468
PubMed: 31541571
PubMed Central: PMC7530546

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000221
to stream Main, to step Curation: 000221

Le document en format XML

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<term>Bacterial Proteins (metabolism)</term>
<term>Cervix Uteri (cytology)</term>
<term>Epithelial Cells (microbiology)</term>
<term>Female (MeSH)</term>
<term>Gene Deletion (MeSH)</term>
<term>Gene Expression Regulation, Bacterial (MeSH)</term>
<term>Gonorrhea (metabolism)</term>
<term>Gonorrhea (microbiology)</term>
<term>Humans (MeSH)</term>
<term>Iron (metabolism)</term>
<term>L-Lactate Dehydrogenase (genetics)</term>
<term>L-Lactate Dehydrogenase (metabolism)</term>
<term>Microbial Viability (genetics)</term>
<term>Neisseria gonorrhoeae (enzymology)</term>
<term>Neisseria gonorrhoeae (genetics)</term>
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<term>Délétion de gène (MeSH)</term>
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<term>Fer (métabolisme)</term>
<term>Gonorrhée (microbiologie)</term>
<term>Gonorrhée (métabolisme)</term>
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<term>L-Lactate dehydrogenase (métabolisme)</term>
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<term>Protéines bactériennes (génétique)</term>
<term>Protéines bactériennes (métabolisme)</term>
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<term>Viabilité microbienne (génétique)</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Bacterial Proteins</term>
<term>L-Lactate Dehydrogenase</term>
<term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Bacterial Proteins</term>
<term>Iron</term>
<term>L-Lactate Dehydrogenase</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Neisseria gonorrhoeae</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Col de l'utérus</term>
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</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Microbial Viability</term>
<term>Neisseria gonorrhoeae</term>
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<term>L-Lactate dehydrogenase</term>
<term>Neisseria gonorrhoeae</term>
<term>Protéines bactériennes</term>
<term>Viabilité microbienne</term>
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<term>L-Lactate dehydrogenase</term>
<term>Protéines bactériennes</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">L-lactate is an abundant metabolite in a number of niches in host organisms and represents an important carbon source for bacterial pathogens such as Neisseria gonorrhoeae. In this study, we describe an alternative, iron-sulfur cluster-containing L-lactate dehydrogenase (LutACB), that is distinct from the flavoprotein L-lactate dehydrogenase (LldD). Expression of lutACB was found to be positively regulated by iron, whereas lldD was more highly expressed under conditions of iron-limitation. The functional role of LutACB and LldD was reflected in in vitro studies of growth and in the survival of N gonorrhoeae in primary cervical epithelial cells.</div>
</front>
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<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>21</Day>
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<Month>10</Month>
<Day>09</Day>
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<Issue>3</Issue>
<PubDate><Year>2020</Year>
<Month>01</Month>
<Day>14</Day>
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<Title>The Journal of infectious diseases</Title>
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<ArticleTitle>Two Distinct L-Lactate Dehydrogenases Play a Role in the Survival of Neisseria gonorrhoeae in Cervical Epithelial Cells.</ArticleTitle>
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<Abstract><AbstractText>L-lactate is an abundant metabolite in a number of niches in host organisms and represents an important carbon source for bacterial pathogens such as Neisseria gonorrhoeae. In this study, we describe an alternative, iron-sulfur cluster-containing L-lactate dehydrogenase (LutACB), that is distinct from the flavoprotein L-lactate dehydrogenase (LldD). Expression of lutACB was found to be positively regulated by iron, whereas lldD was more highly expressed under conditions of iron-limitation. The functional role of LutACB and LldD was reflected in in vitro studies of growth and in the survival of N gonorrhoeae in primary cervical epithelial cells.</AbstractText>
<CopyrightInformation>© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Nathan H</ForeName>
<Initials>NH</Initials>
<AffiliationInfo><Affiliation>School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, St. Lucia, Queensland, Australia.</Affiliation>
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<ForeName>Cheryl-Lynn Y</ForeName>
<Initials>CY</Initials>
<AffiliationInfo><Affiliation>School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, St. Lucia, Queensland, Australia.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>O'sullivan</LastName>
<ForeName>Jonathan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, St. Lucia, Queensland, Australia.</Affiliation>
</AffiliationInfo>
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<ForeName>Ines</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, St. Lucia, Queensland, Australia.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Davey</LastName>
<ForeName>Krystelle</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, St. Lucia, Queensland, Australia.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Edwards</LastName>
<ForeName>Jennifer L</ForeName>
<Initials>JL</Initials>
<AffiliationInfo><Affiliation>Center for Microbial Pathogenesis, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.</Affiliation>
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<Language>eng</Language>
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<Acronym>AI</Acronym>
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<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D002584" MajorTopicYN="N">Cervix Uteri</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName>
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<MeshHeading><DescriptorName UI="D004847" MajorTopicYN="N">Epithelial Cells</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D017353" MajorTopicYN="N">Gene Deletion</DescriptorName>
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Two Distinct L-Lactate Dehydrogenases Play a Role in the Survival of Neisseria gonorrhoeae in Cervical Epithelial Cells.

Two Distinct L-Lactate Dehydrogenases Play a Role in the Survival of Neisseria gonorrhoeae in Cervical Epithelial Cells.

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